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| Risk-related Studies |
| Alyaudtin, R. N., Reichel, A., Lobenberg, R., Ramge, P., Kreuter, J., Begley, D. J. (2001). Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro. Journal of Drug Targeting, 9(3), 209-221. |
| Bodian, D. & Howe, H. (1941). The rate of progression of poliomyelitis virus in nerves. Bulletin of Johns Hopkins Hospital, 69(2): 79-85. |
| DeLorenzo, A. (1970). The olfactory neuron and the blood-brain barrier. In Taste and Smell in Vertebrates (G. Wolstenholme, J. Knight, Eds.) CIBA Foundation Symposium Series. London: J & A Churchill, pp. 151-176. Kreuter, J. (2004). Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. Journal of Nanoscience and Nanotechnology, 4, 484-488. |
| Elder, A., Gelein, R., Silva, V., Feikert, T., Opanashuk, L., Carter, J., Potter, R., Maynard, A., Ito, Y. Finkelstein, J., and Oberdörster, G. (August 2006). Translocation of inhaled ultrafine manganese oxide particles to the central nervous system . Environmental health perspectives, Volume 114, Number 8: 1172 -1178. Abstract. Article |
| Federici, G., Shaw, B.J., Handy, R.D. (October 2007). Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physiological effects. Aquatic Toxicology, 84 (4): 415-430. |
| Kreuter, J. (2004). Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain. Journal of Nanoscience and Nanotechnology, 4, 484-488. |
| Kreuter, J., Ramge, P., Petrov,V., Hamm, S., Gelperina, S. E., Engelhardt, B., Alyautdin, R., von Briesen, H. & Begley, D. J. (2003). Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nano particles. Pharm. Res. 20, 409-416. |
| Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P. Cychutek, K., Koch-Brandt, C., Alyautdin, R. (2002). Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. Journal of Drug Targeting, 10(4), 317-325. |
| Long, T.C., Saleh, N., Tilton, R.D., Lowry, G.V., and Veronesi, B. (2006). Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2): Implications for Nanoparticle Neurotoxicity. Environmental Science and Technology, 40 (14), 4346 -4352. Abstract |
| Long, T.C., Tajuba, J., Sama, P. et al. (November 2007). Nanosize Titanium Dioxide Stimulates Reactive Oxygen Species in Brain Microglia and Damages Neurons in Vitro. Environmental Health Perspectives, 115(11): 1631-1637. Abstract. |
| Minn, A., Leclerc, S., Heydel, J., Minn, A., Denizot, C., & Cattarelli, M. et al. (2002). Drug transport into the mammalian brain: The nasal pathway and its specific metabolic barrier. Journal of Drug Targeting, 10, 285-296. |
| Muller, R. H., & Keck, C. M. (2004). Drug delivery to the brain-realization by novel drug carriers. Journal of Nanoscience and Nanotechnology, 4, 471-483. |
| Tsao, N., Wu, C. M., Hsu, Liu, C. C., Luh, T. Y., Chou, C. K., et al. (2001). Inhibition of the increased permeability of blood-brain barrier in Escherichia coli-induced meningitis by carboxyfullerenne. Fullerene Science & Technology, 9: 307-320. |
| Oberdorster, E. 2004a. Manufactured nanomaterials (fullerenes, C 60) induce oxidative stress in the brain of juvenile largemouth bass. Environmental Health Perspectives, 112(10), 1058-1062. |
| Oberdorster, G., Sharp, S., Atudorei, V., Elder, A., Gelein, R. Kreyling, W. et al. (2004).Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology, 46, 437-445. |
| - NEW - Tang, M., Xing, T., Zeng, J. et al. (July 2008). Unmodified CdSe Quantum Dots Induce Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons. Environmental Health Perspectives, 116(7): 915-922. Abstract. |
| Tsuchiya, T., Oguri, I., Nakajima, Y., Yamakoshi, N., Miyata, N. (1996). Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Letters, 393: 139-145. |
| Ueng, T.H., Kang, J. J., Wang, H. W., Cheng, Y. W., Chiang, L. Y. (1997). Suppression of microsomal cytochrome P450-dependent monooxygenases and nitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60. |
| Zara, G. P., Cavalli, R., Bargoni, A., Fundaro, A., Vighetto, D., & Gasco, M. R. (2002). Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxorubicin in brain and other tissues. Journal of Drug Targeting, 10, 327-335. |
