UW NSEC

Back to Nanotechnology Risk Resources Mainpage


Afaq, F., Abidi, P., Matin, R., Rahman, Q. (1998). Cytotoxicity, prooxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultra-fine titanium dioxide. Applied Toxicology, 18, 307-312.
Asgharian, B, Price, O.T. (2007). Deposition of Ultrafine (NANO) Particles in the Human Lung. Inhalation Toxicology, 19(3): 1045-1054. Abstract.
- NEW - Alessandrini, F., Semmler-Behnke, M., Jakob, T. et al. (April 2008). Total and Regional Deposition of Ultrafine Particles in a Mouse Model of Allergic Inflammation of the Lung. Inhalation Toxicology, 20(6): 585-593. Abstract.
Baggs, R. B., Fern, J., Gelein, R., Soderholm, S. C., Finkelsstein, J. (1997). Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Veterinary Pathology, 34, 592-597.
- NEW - Balásházy, I., Hofmann, W., Farkas, A., Madas, B.G. (April 2008). Three-Dimensional Model for Aerosol Transport and Deposition in Expanding and Contracting Alveoli. Inhalation Toxicology, 20(6): 611-621. Abstract.
Bermudez, E., Mangum, J. B., Asgharian, B., Wong. B. A., Reverdy, E. E., Janszen, D. B., Haxt, P. M., Warhiet, D. B., Everitt, J. I. (2002). Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicological Sciences , 70, 86-97.
Bermudez, E., Mangum, J. S., Wong, B. A., Asgharian, B., Hext, P. M., Warheit, D. B., Everitt, J. I. (2004). Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicological Sciences, 77, 347-357.
Carrero-Sánchez, J. C. ., Elías, A. L., Mancilla, R., Arrellín, G., Terrones, H., Laclette, J. P., and Terrones, M. (2006). Biocompatibility and Toxicological Studies of Carbon Nanotubes Doped with Nitrogen. Nano Letters, 6(8) pp 1609 - 1616 Abstract.
- NEW - Chou, C-C., Hsiao, H-Y., et al. (2008). Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model. Nano Lett. Abstract.
Churg, A., Stevens, B., Wright, J. (1998). Comparison of the uptake of fine and ultrafine TiO2 in a tracheal explant system. American Journal of Physiology, 274, L81-L86.
Cormier, S.A., Lomnicki, S., Backes, W., and Dellinger, B. (June 2006). Origin and Health Impacts of Emissions of Toxic By-Products and Fine Particles from Combustion and Thermal Treatment of Hazardous Wastes and Materials. Environmental Health Perspectives, 114(6): 810–817. Article.
Dailey, L.A., Jekel, N., Fink, L., Gessler, T., Schmehl, T., Wittmar, M., Kissel, T., and Seeger, W. (August 2006). Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung. Toxicology and Applied Pharmacology. Volume 215, Issue 1: 100-108. Abstract. Article
Davoren, M., Herzog, E., Casey, A., Cottineau, B., Chambers, G., Byrne, H.J., Lyng, F.M. (April 2007). In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells. Toxicology in vitro, 21(3): 438-448.
Donaldson, K. Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., and Alexander, A. (2006). Carbon nanotubes: A review of their properties in relation to pulmonary toxicological and workplace safety. Toxicological Sciences, 92(1):5-22 Article
Duffin, R; Mills, NL; Donaldson, K. (August 2007). Nanoparticles - A thoracic toxicology perspective. Yonsei medical journal, 48 (4): 561-572. Article.
Elder, A., Yang, H., Gwiazda, R. (October 2007). Testing nanomaterials of unknown toxicity: An example based on platinum nanoparticles of different shapes. Advanced materials, 19 (20): 3124. Abstract.
Gauderman, J.W. (January 2007). Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. The Lancet, Early Online Publication. Abstract.
Geiser, M., Rothen-Rutishauser, B., Kapp, N., Schürch, S., Kreyling, W., et al. (November 2005). Ultrafine Particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environmental Health Perspectives, Volume 113, 11.
Gerlofs-Nijland, M.E, Dormans, J.A.M.A, Bloemen, H.J.T. et al. (October 2007). Toxicity of Coarse and Fine Particulate Matter from Sites with Contrasting Traffic Profiles. Inhalation Toxicology, 19(13): 1055-1069. Abstract.
Ghio, A.J., Funkhouser, W., Pugh, C.B., Winters, S., Stonehuerner, A., Roggli, V.L. (2006). Pulmonary Fibrosis and Ferruginous Bodis Associated with Exposure to Synthtic Fibers. Toxicologic Pathology, Volume 34: 723-729.
Grassian, V.H., O’Shaughnessy, P.T., Adamcakova-Dodd, Q., Pettibone, J.M., Thorne, P.S. (March 2007). Inhalation Exposure Study of Titanium Dioxide Nanoparticles with a Primary Particle Size of 2 to 5 nm. Environ Health Perspect, 115(3): 397–402. Article.
Grubek-Jaworska, H., Nejman P., Czumin´ska, K., Przybylowski, T., Huczko, A., Lange, H., Bystrzejewski, M., Baranowski, P., Chazan, R. (2006). Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons. Carbon, 44: 1057–1063
Hamilton Jr, R.F., Buford, M.C., Wood, M.B. et al. (June 2007). Engineered carbon nanoparticles alter macrophage immune function and initiate airway hyper-responsiveness in the BALB/c mouse model. Nanotoxicology, 1(2): 104-117. Article
- NEW - Han, SG; Andrews, R; Gairola, CG; Bhalla, DK. (February 2008). Acute pulmonary effects of combined exposure to carbon nanotubes and ozone in mice. Inhalation Toxicology, 20 (4): 391-398. Abstract
- NEW - Handy, RD; Owen, R; Valsami-Jones, E. (July 2008). The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs. Ecotoxicology, 17(5): 315-447. Abstract
Happo, M.S., Salonen, R.O., Hälinen, A.I. (March 2007). Dose and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine particles from six European cities. Inhal Toxicol., 19(3):227-46. Abstract.
Inoue, K., Takano, H., Yanagisawa, R., Hirano, S., Sakurai, M., Shimada, A., and Yoshikawa, T. (September 2006). Effects of Airway Exposure to Nanoparticles on Lung Inflammation Induced by Bacterial Endotoxin in Mice. Environmental Health Perspectives, Volume 114, Number 9. Abstract.
Kaewamatawong, T. Shimada, A., Okajima, A. (January 2006). Acute and Subacute Pulmonary Toxicity of Low Dose of Ultrafine Colloidal Silica Particles in Mice after Intratracheal Instillation. Toxicologic Pathology, 34(7): 958-965. Article.
Kisin, E.R., Murray, A.R, Keane, M.J. et al. (December 2007). Single-walled Carbon Nanotubes: Geno- and Cytotoxic Effects in Lung Fibroblast V79 Cells. J Toxicol Environ Health A 2007, 70(24): 2071-9. Abstract.
Kisin, E., Jurray, A. R., Johnson, et al. (2005). Pulmonary toxicity of carbon nanotubes. Toxicologist, 84(Suppl 1), 212.
Kreyling, G.K., Semmler-Behnke, M., Möller, W. (2006). Ultrafine particle-lung interactions: does size matter? Journal of Aerosol Medicine, Volume 19, 1: 74-83.
Lee, K.P., Trochomowicz, & Reinhardt, C. F. (1985). Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicology and Applied Pharmacology, 79, 179-192.
- NEW - Li, N; Xia, T; Nel, AE. (May 2008). The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free radical biology & medicine, 44(9): 1689-1699. Abstract
- NEW - Li, JJ; Zou, L; Hartono, D, et al. (January 2008). Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro. Advanced materials, 20 (1): 138-142. Abstract
Li, J.A., Li, Q.N., Xu, J.Y. et al. (November 2007). Comparative study on the acute pulmonary toxicity induced by 3 and 20 nm TiO2 primary particles in mice. Environmental toxicology and pharmacology, 24 (3): 239-244.
Li, S., Salmen, R., Hulderman, T., Kisin, E., Shvedova, A., Luster, M. & Simeonova, P. (2004). Pulmonary carbon nanotube exposure and oxidative status in vascular system. Free Radical Biology & Medicine, 37(Suppl 1), S142-S143.
Limbach, L.K., Wick, P., Manser, P. et al. (2007). Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress. Environ. Sci. Technol., 41: 4158–4163. Abstract.
Limbach, L.K., Li, Y. et ali. (2005). Oxide Nanoparticle Uptake in Human Lung Fibroblasts: Effects of Particle Size, Agglomeration, and Diffusion at Low Concentrations. Environ. Sci. Technol., 39(23): 9370 - 9376. Abstract.
- NEW - Mercer, R.R., Scabilloni, J.F., Wang, L. et al. (2008). Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single walled carbon nanotubes in a mouse model. Am J Physiol Lung Cell Mol Physio, 294: L87-L97. Abstract.
Mercer, R. R., Scaillonia, J., Kisin, K., et al. (2005). Responses of lung parenchyma to carbon nanotubes. Toxicologist, 84(Suppl1), 213.
Mitchell, L.A., Gao, J., Wal, R.V. et al. (November 2007). Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicological Sciences, 100 (1): 203-214. Abstract.
Mossman, B.T., Borm, P.j., Castranova, V., Costa, D.L., Donaldson, K. and Kleeberger, R.S. (May 2007). Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases. Particle and Fibre Toxicology, 4:4. Abstract.
- NEW - Muhlfeld, C; Rothen-Rutishauser, B; Blank, F; Vanhecke, D; Ochs, M; Gehr, P. (May 2008). Interactions of nanoparticles with pulmonary structures and cellular responses. American journal of physiology. Lung cellular and molecular physiology, 294: L817-L829. Abstract.
- NEW - Muller, J; Decordier, I; Hoet, PH, et al. (February 2008). Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis, 29 (2): 427-433. Abstract.
Muller, J., Huaux, F., Lison, D. (2006). Respiratory toxicity of carbon nanotubes: How worried should we be? Carbon, 44: 1048–1056
Muller, J., Huax, F., Moreau, N., Misson, P. Heilier, J. F., Delos, M., Arras, M., Fonseca, A., Nagy, J. B., & Lison, D. (2005). Respiratory toxicity of multi-wall carbon nanotubes. Toxicology and Applied Pharmacology, In Press.
- NEW - Nazridoust, K., Asgharian, B. (April 2008). Unsteady-State Airflow and Particle Deposition in a Three-Generation Human Lung Geometry. Inhalation Toxicology, 20(6): 595-610. Abstract.
- NEW - Niwa, Y., Hiura, Y., Sawamura, H., Iwai, N. (January 2008). Inhalation exposure to carbon black induces inflammatory response in rats. Circulation Journal, 72 (1): 144-149. Article.
- NEW - Park, B., Donaldson, K., Duffin, R. et al. (April 2008). Hazard and Risk Assessment of a Nanoparticulate Cerium Oxide-Based Diesel Fuel Additive—A Case Study. Inhalation Toxicology, 20(6): 547-566. Abstract.
- NEW - Poland, C.A., Duffin, R., Kinloch, I. et al. (2008). Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotechnology, Published online: 20 May 2008. Abstract.
- NEW - Sayes, C.M. and Warheit, D.B. (2008). An in vitro investigation of the differential cytotoxic responses of human and rat lung epithelial cell lines using TiO2 nanoparticles. International Journal of Nanotechnology, 5(1):15 - 29. Abstract
- NEW - Shah, A.P., Pietropaoli, A.P., Frasier; L.M. et al. (March 2008). Effect of Inhaled Carbon Ultrafine Particles on Reactive Hyperemia in Healthy Human Subjects. Environmental Health Perspectives, 116(3): 375–380. Article
Sharma, C.S., Sarkar, S., Periyakaruppan, A. et al. (July 2007). Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells, Journal of Nanoscience and Nanotechnology, 7 (7): 2466-2472. Abstract
- NEW - Shvedova, A.A., Fabisiak, J.P., Kisin, E.R. et al. (2008). Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity.American journal of respiratory cell and molecular biology, 38(5): 579-590. Abstract
Shvedova, A.A., Kisin, E.R., Mercer, R., et al. (2005). Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. American Journal of Physiology, Lung, 289, 698-708.
Singh, S., Shi, T.M., Duffin, R. et al. (July 2007). Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: Role of the specific surface area and of surface methylation of the particles. Toxicology And Applied Pharmacology, 222 (2): 141-151. Article
- NEW - Soto, K. (March 2008). Direct contact cytotoxicity assays for filter-collected, carbonaceous (soot) nanoparticulate material and observations of lung cell response. Atmospheric environment, 42 (9): 1970-1982. Abstract
Soto, K., Garza, K.M. and Murr, L.E. (2007). Cytotoxic effects of aggregated nanomaterials. Acta Biomater., 3: 351–358. Abstract
Wallace, W.E., Keane, M.J., Murray, D.K., Chisholm, W.P., Maynard, A.D., and Ong, T.M. (January 2007). Phospholipid lung surfactant and nanoparticle surface toxicity: Lessons from diesel soots and silicate dusts. Journal of Nanoparticle Research, 9,1: 23-38. Abstract.
Warheit, D.B. (2006). What is currently known about the health risks related to carbon nanotube exposures? Carbon, 44: 1064–1069
Warheit et al. (2006). Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats.Toxicological Sciences. Advanced copy available online.  Abstract
Wörle-Knirsch, J.M., Kern, K., Schleh, C., Adelhelm, C., Feldmann, C. and Krug, H.F. (January 2007). Nanoparticulate Vanadium Oxide Potentiated Vanadium Toxicity in Human Lung Cells. Environmental Science and Technology, 41 (1): 331 -336.
Yamawaki, H., and Iwai, N. (January 2006). Cytotoxicity of water soluble fullerene in vascular endothelial cells. American Journal of Physiology, 290: 1495 – 1502. Abstract. Article
Yacobi, NR; Phuleria, HC. et al. (December 2007). Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicology in Vitro, 21(8): 1373-1381.
- NEW - Zhu, MT; Feng, WY; Wang, B; et al. (May 2008). Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology, 247 (2-3): 102-111.

Last updated July 2008 - Mathilde Colin